Process Development & Optimization

Analytical Chemistry

Thousands of samples from the microbiology and chemistry laboratories, and the fermentation suites are analyzed in the analytical chemistry laboratory annually. The analyzes provide data and trending for process improvement in terms of growth, media components, titre, and impurities.

Most of the samples are analyzed using one of ten fully computerized HPLCs with autosamplers. Numerous detectors are available including variable wavelength UV-visible, photodiode array, refractive index, evaporative light scattering, fluorescence and a time of flight mass spectrometer. The laboratory is also equipped with a UV-visible spectrophotometer, a gas chromatograph, biochemistry analyzers and a Karl Fischer titration.