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The API is isolated and extracted from fermentation broth in our isolation plant using either aqueous or solvent-based processes. Initial separation is typically through a filter press with subsequent processing of the filtrate or filter cake to isolate and extract the product using aqueous or solvent based processes.
The isolation plant is a Class 1 Division 1 plant for flammable liquid processing.
Equipment available for separation/filtration includes a 70 plate filter press (70 m2), decanter centrifuge, nanofiltration system and box filters. Equipment available for extraction includes a Podbielniak centrifugal liquid-liquid extractor and holding vessels and reactors ranging in size from 7,000L to 15,000L.
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